Normal bone marrow; Normal granulocytes and erythroblasts are evident.
B:
Acute lymphoid leukemia (ALL); The marked proliferation of small lymphoblasts is evident.
C:
Acute myeloid leukemia (AML); The marked proliferation of large myeloblasts is evident.
D:
Chronic myeloid leukemia (CML); There is a marked proliferation of granulocytes at various stages of maturation.
E: Crude incidence of leukemia by type
(Radiation Effects Research Foundation Life Span Study, 1950-1987)
E:
A dose response relationship was recognized in acute lymphoid leukemia (ALL), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML).
According to research to date, radiation-induced leukemia, unlike
solid tumors, appears from as early as two years after atomic bomb exposure and peaks five to seven years after exposure. It is also known that the excess relative risk is higher the lower the age of the exposed person at the time of the atomic bombing.
[Cited and modified from Preston DL, et al., Radiat Res 137:S68-S97, 1994]
